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metadata.dc.type: Artigo de Periódico
Título : Macrophages participate in host protection and the disease pathology associated with Leishmania braziliensis infection
Otros títulos : BMC Infectious Diseases
Autor : Giudice, Angela
Vendrame, Célia
Bezerra, Caroline A.
Carvalho, Lucas Pedreira de
Delavechia, Thaís
Carvalho Filho, Edgar Marcelino de
Bacellar, Maria Olívia Amado Ramos
metadata.dc.creator: Giudice, Angela
Vendrame, Célia
Bezerra, Caroline A.
Carvalho, Lucas Pedreira de
Delavechia, Thaís
Carvalho Filho, Edgar Marcelino de
Bacellar, Maria Olívia Amado Ramos
Resumen : Background Leishmania preferentially infects macrophages, which allow the parasite to multiply but can also kill the parasite. Although the T cell response in human leishmaniasis is well-characterized, little is known about the concomitant macrophage behavior. The aim of this study was to characterize the macrophage immune response after Leishmania braziliensis infection in cells derived from cutaneous leishmaniasis (CL) or mucosal leishmaniasis (ML) patients, subclinical individuals (SC) and healthy control subjects (HS). Methods Peripheral blood mononuclear cell-derived macrophages from the different groups were exposed to L. braziliensis in vitro and were evaluated for susceptibility to Leishmania infection, ability to kill Leishmania and chemokine/cytokine production. Nitric Oxide (NO) and superoxide (O2-) levels in the supernatant of infected macrophage cultures were monitored. Results After exposure to L. braziliensis, peripheral blood mononuclear cell-derived macrophages from SC individuals showed a lower infection rate and a smaller number of intracellular amastigotes compared to cells from CL and ML patients. Macrophages from CL and ML patients produced more chemokines and TNF-α than those from the SC group. Production of NO and O2- were detected but did not vary significantly among the different groups. Conclusions Our data indicate that macrophages play a pivotal role in controlling L. braziliensis infection and in leishmaniasis pathology by secreting pro-inflammatory chemokines/cytokines that activate and recruit T cells, overwhelming the inflammatory response.
Palabras clave : L braziliensis
Macrophages
Chemokines
Subclinical infection
metadata.dc.rights: Acesso Aberto
URI : http://repositorio.ufba.br/ri/handle/ri/16189
Fecha de publicación : 2012
Aparece en las colecciones: Artigo Publicado em Periódico (Faculdade de Medicina)

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