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metadata.dc.type: | Artigo de Periódico |
Title: | Evaluating total lymphocyte counts as a substitute for CD4 counts in the follow up of AIDS patients |
Other Titles: | Brazilian Journal of Infectious Diseases |
Authors: | Angelo, Ana Luiza Dias Angelo, Camila Dias Torres, Alex José Leite Ramos, André Maurício Costa Lima, Márcia Martins Netto, Eduardo Brites, Carlos |
metadata.dc.creator: | Angelo, Ana Luiza Dias Angelo, Camila Dias Torres, Alex José Leite Ramos, André Maurício Costa Lima, Márcia Martins Netto, Eduardo Brites, Carlos |
Abstract: | This study evaluated total lymphocyte count (TLC) as a substitute marker for CD4+ cell counts to identify patients who need prophylaxis against opportunistic infection (CD4 < 200 cells/mm3) and patients with CD4 < 350 cells/mm3 (Brazilian threshold value of CD4 count to define AIDS). We evaluated TLC and CD4+ cells count of 1,174 HIV-infected patients, in Salvador, Brazil, from May 2003 to September 2004. CD4+ cell counts were performed by flow cytometry, and TLC was measured with an automated hematological counter. The mean CD4 count was 430 cells/mm3 (range: 4 to 2,531 cells/mm3). Mean TLC was 1,900 cells/mm3 (range: 300 to 6,200 cells/mm3). Using a threshold value of 1,000 cells/mm3 for TLC, the positive predictive value (PPV) was 77% for CD4 < 200 cells/mm3, but the sensitivity was only 29%, while the negative predictive value (NPV) was 88%, with 98% specificity. Similar findings were observed for CD4 count < 350. Using the same threshold value of 1,000 cells/mm3 for TLC, sensitivity was 14%, and specificity 99% (PPV= 94%; NPV=62%). In 70/1,510 (5%) of the samples the sum of CD4 and CD8 cell counts was greater than the TLC and in 27% (419/1,510) this sum was below 65% of the TLC. TLC has a high specificity to identify patients for prophylaxis, but a quite low sensitivity. It is not useful as an alternative to CD4+ T-cell counts as a marker in HIV-infected patients. |
Keywords: | Lymphocyte counts CD4 counts AIDS |
Publisher: | The Brazilian Journal of Infectious Diseases and Contexto Publishing |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/6702 |
Issue Date: | Oct-2007 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Files in This Item:
File | Description | Size | Format | |
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Angelo, Ana Luiza Dias.pdf | 85,63 kB | Adobe PDF | View/Open |
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