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https://repositorio.ufba.br/handle/ri/8341
metadata.dc.type: | Artigo de Periódico |
Título : | Cytokine profile associated with human chronic schistosomiasis mansoni |
Otros títulos : | Memórias do Instituto Oswaldo Cruz. |
Autor : | Magalhães, Andréa Miranda, Delfin Gonzalez Miranda, Roberval Gonzalez Araujo, Maria Ilma Andrade Santos Jesus, Adriana Almeida de |
metadata.dc.creator: | Magalhães, Andréa Miranda, Delfin Gonzalez Miranda, Roberval Gonzalez Araujo, Maria Ilma Andrade Santos Jesus, Adriana Almeida de |
Resumen : | This study objective was to evaluate the cytokines associated with early events of hepatic fibrosis in schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography in 94 patients.Immunological evaluation was performed by measurement of secreted cytokines (interleukin IL-5, IL-10, IL-13, interferon-g, tumor necrosis factor-a and transforming growth factors-b) in peripherl blood mononuclear cells stimulated by Schistosoma mansoni antigens. Significantly, higher levels of IL-5, IL-10 and IL-13 were found in supernatants of SEA-stimulated PBMC from subjects with degree III hepatic fibrosis as compared to patients with degree I or II fibrosis, Significant increases in IL-5 and IL-13 levels were also observed in some of the subjects who remained untreated for one year following initial assessment and developed more serious fibrosis during this period. The data suggests a role for type 2 cytokines in early stages of hepatic fibrosis in human schistosomiasis mansoni. |
Palabras clave : | schistosomiasis hepatic fibrosis interleukin-5 interleukin-13 |
URI : | http://www.repositorio.ufba.br/ri/handle/ri/8341 |
Fecha de publicación : | 2004 |
Aparece en las colecciones: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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v99s1a04.pdf | 91,36 kB | Adobe PDF | Visualizar/Abrir |
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