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https://repositorio.ufba.br/handle/ri/7767
metadata.dc.type: | Artigo de Periódico |
Title: | Rheumatoid arthritis induced by alpha interferon therapy |
Other Titles: | Clinical Rheumatology |
Authors: | Souza, E. Passos de Evangelista Segundo, P. Teles José, Fábio Freire Lemaire, Denise Carneiro Santiago, M. |
metadata.dc.creator: | Souza, E. Passos de Evangelista Segundo, P. Teles José, Fábio Freire Lemaire, Denise Carneiro Santiago, M. |
Abstract: | Interferon (IFN) therapy has been used for the treatment of common diseases such as hepatitis C, myeloproliferative disorders, autoimmune diseases and various types of cancer. Given the biological properties of interferon, it is not surprising that there are a larger number of side effects due to its use. Although rheumatoid arthritis (RA) is one of the most common autoimmune diseases found in clinical practice, it does not seem to be frequently related to IFN therapy. We report a 40-year-old female patient who, after high doses of IFN-α therapy for malignant melanoma, developed symmetrical polyarthritis, with pain and oedema in small and large joints, associated with prolonged morning stiffness. She had positive rheumatoid factor and DR4 HLA phenotype. She was treated with deflazacort (6 mg/day), chloroquine and NSAIDs, with a partial response. In conclusion, although the development of RA after IFN therapy is a rare event, IFN may work as a ‘trigger’ for such complication, leading to deregulation in the immune cascade in a person genetically predisposed. |
Keywords: | Rheumatoid arthritis α-interferon |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/7767 |
Issue Date: | 2001 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Files in This Item:
File | Description | Size | Format | |
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Lemaire.pdf Restricted Access | 54,63 kB | Adobe PDF | View/Open Request a copy |
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