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https://repositorio.ufba.br/handle/ri/7026
metadata.dc.type: | Artigo de Periódico |
Título : | Cytologic alterations in the oral mucosa after chronic exposure to ethanol |
Otros títulos : | Brazilian Oral Research |
Autor : | Reis, Sílvia Regina de Almeida Espírito Santo, Alexandre Ribeiro do Andrade, Miguel Gustavo Setúbal Sadigursky, Moysés |
metadata.dc.creator: | Reis, Sílvia Regina de Almeida Espírito Santo, Alexandre Ribeiro do Andrade, Miguel Gustavo Setúbal Sadigursky, Moysés |
Resumen : | The effects of ethanol alone on the oral mucosa are still poorly understood, especially because there are few non-smoking chronic consumers of alcoholic beverages. The aim of this study was to evaluate the frequency of micronucleus, abnormal nucleus/cytoplasm ratio, pyknosis, karyorrhexis and karyolysis in exfoliated cells from the buccal mucosa and from the lateral border of the tongue in 36 non-smoker alcoholics (ethanol group) and 18 non-smokers and non-drinkers (control group). The Papanicolaou method was used. Since alcoholics generally have hepatobiliary involvement, the association between serum gamma-glutamyl transpeptidase (GGT) and some of the analyzed oral mucosa alterations was also investigated. The ethanol group showed a significant increase in the frequency of all alterations analyzed in the tongue cells when compared with the control group (p < 0.01; Mann-Whitney). However, the presence of these changes in buccal mucosa cells was not statistically significant (p > 0.05; Mann-Whitney). In the ethanol group, the correlation between serum GGT and the frequency of micronucleus and abnormal nucleus/cytoplasm ratio in oral mucosa cells was not significant (p > 0.05; Spearman). In conclusion, chronic exposure to ethanol may be associated with carcinogenic cytologic changes in the oral mucosa, even in the absence of tobacco smoking. These alterations were not correlated with hepatobiliary injury. |
Palabras clave : | Cytology Mouth mucosa Ethanol Carcinogens |
Editorial : | Sociedade Brasileira de Pesquisa Odontológica |
URI : | http://www.repositorio.ufba.br/ri/handle/ri/7026 |
Fecha de publicación : | abr-2006 |
Aparece en las colecciones: | Artigo Publicado em Periódico (Faculdade de Odontologia) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Reis, Sílvia Regina de Almeida.pdf | 223,29 kB | Adobe PDF | Visualizar/Abrir |
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