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metadata.dc.type: | Artigo de Periódico |
Title: | Effect of the intracerebroventricular administration of GR 113808, a selective 5-HT4 antagonist, on water intake during hyperosmolarity and hypovolemia |
Other Titles: | Brazilian Journal of Medical and Biological Research |
Authors: | Castro, L. Varjão, B. Silva, I. Duque, Bruno Batista, A. Santana, R. Luz, P. Rocha Junior, M. A. Fregoneze, J. B. Castro e Silva, E. de |
metadata.dc.creator: | Castro, L. Varjão, B. Silva, I. Duque, Bruno Batista, A. Santana, R. Luz, P. Rocha Junior, M. A. Fregoneze, J. B. Castro e Silva, E. de |
Abstract: | We demonstrate here that acute third ventricle injections of GR 113808, a highly selective 5-HT4 antagonist, decrease water intake induced by a previous salt load while potentiating drinking elicited by hypovolemia induced by previous subcutaneous administration of polyethylene glycol in male Wistar rats (200 ± 20 g). At the dose of 160 nmol/rat, third ventricle injections of GR 113808 induced a significant reduction of water intake in salt-loaded animals after 120 min as compared to salt-loaded animals receiving third ventricle injections of saline (salt load + GR = 3.44 ± 0.41 ml, N = 12; salt load + saline = 5.74 ± 0.40 ml, N = 9). At the dose of 80 nmol/rat, GR 113808 significantly enhanced water intake in hypovolemic animals after 120 min as compared to hypovolemic animals receiving third ventricle injections of saline (hypovol + GR = 4.01 ± 0.27 ml, N = 8; hypovol + saline = 2.41 ± 0.23 ml, N = 12). We suggest that central 5-HT4 receptors may exert a positive drive on water intake due to hyperosmolarity and a negative input on drinking provoked by hypovolemia. |
Keywords: | 5-HT4 receptors Water intake Hyperosmolarity Hypovolemia |
Publisher: | Brazilian Journal of Medical and Biological Research |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/6828 |
Issue Date: | Jun-2001 |
Appears in Collections: | Artigo Publicado em Periódico (Biologia) |
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