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metadata.dc.type: | Artigo de Periódico |
Title: | Role of central 5-HT3 receptors in the control of blood pressure in stressed and non-stressed rats |
Other Titles: | Brain Research |
Authors: | Ferreira, Hilda Silva Silva, Emilio de Castro e Cointeiro, Carla Oliveira, Elenilda Faustino, Thiallan Nery Fregoneze, Josmara Bartolomei |
metadata.dc.creator: | Ferreira, Hilda Silva Silva, Emilio de Castro e Cointeiro, Carla Oliveira, Elenilda Faustino, Thiallan Nery Fregoneze, Josmara Bartolomei |
Abstract: | The aim of the present study was to investigate the participation of central 5-HT3 receptors in the control of blood pressure and heart rate (HR) of non-stressed and stressed rats. The pharmacological stimulation of brain 5-HT3 receptors by third ventricle injections of the selective 5-HT3 receptor agonist m-CPBG induced a significant decrease in blood pressure in non-stressed rats and impaired the hypertensive response induced by restraint stress. The blockade of brain 5-HT3 receptors by the central administration of the selective 5-HT3 antagonist ondansetron elicited a significant increase in blood pressure in non-stressed rats. Conversely, the hypertensive response induced by restraint stress was not affected by central administration of ondansetron. Additionally, baroreflex-mediated bradycardia during phenylephrine-induced hypertensive response was preserved in non-stressed animals receiving third ventricle injections of m-CPBG, while the baroreflex-mediated tachycardia that occurs during the hypotensive response induced by the administration of sodium nitroprusside was impaired. It is concluded that the serotoninergic component represented by the brain 5-HT3 receptors exerts a tonic inhibitory influence on the central control of blood pressure in non-stressed rats, probably by a sympathoinhibitory-related mechanism. On the other hand, during stress, this central 5-HT3-dependent inhibitory drive is overwhelmed by the different neurochemical systems that harmonically trigger and sustain the hypertensive response. |
Keywords: | Endocrine and autonomic regulation Cardiovascular regulation |
Publisher: | Elsevier |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/6728 |
Issue Date: | 26-Nov-2004 |
Appears in Collections: | Artigo Publicado em Periódico (ICS) |
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