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https://repositorio.ufba.br/handle/ri/6553
metadata.dc.type: | Artigo de Periódico |
Título : | Effect of the activation of central 5-HT2C receptors by the 5-HT2C agonist mCPP on blood pressure and heart rate in rats |
Otros títulos : | Brain Research |
Autor : | Ferreira, Hilda Silva Oliveira, Elenilda Faustino, Thiallan Nery Silva, Emilio de Castro e Fregoneze, Josmara Bartolomei |
metadata.dc.creator: | Ferreira, Hilda Silva Oliveira, Elenilda Faustino, Thiallan Nery Silva, Emilio de Castro e Fregoneze, Josmara Bartolomei |
Resumen : | n the present study we investigated the role of central 5-HT2C receptors in the control of blood pressure and heart rate in non-stressed and stressed, adult, male, Wistar rats. Third ventricle injections of the 5-HT2C agonist mCPP elicited a significant increase in blood pressure in non-stressed animals. The initial period of this hypertensive response (10–30 min after mCPP administration) was accompanied by baroreflex-mediated bradycardia, while after this period the coexistence of hypertension and tachycardia was observed. These cardiovascular effects promoted by the central administration of mCPP were blocked by pretreatment with the 5-HT2C antagonist, SDZ SER 082. The administration of SDZ SER 082 alone induced no significant changes in blood pressure or heart rate. The pharmacological stimulation of central 5-HT2C receptors by mCPP did not change the hypertensive or tachycardic responses induced by restraint stress. Conversely, the blockade of central 5-HT2C receptors by SDZ SER 082 blunted stress-induced hypertension without modifying stress-induced tachycardia. It is concluded that the activation of central 5-HT2C receptors induces hypertension in non-stressed rats and that the normal function of these receptors is essential for the rise in blood pressure that occurs in the course of restraint stress. |
Palabras clave : | Endocrine and autonomic regulation Cardiovascular regulation |
Editorial : | Elsevier |
URI : | http://www.repositorio.ufba.br/ri/handle/ri/6553 |
Fecha de publicación : | 8-abr-2005 |
Aparece en las colecciones: | Artigo Publicado em Periódico (ICS) |
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