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https://repositorio.ufba.br/handle/ri/6048
metadata.dc.type: | Artigo de Periódico |
Title: | Serum cytokine profile in hepatitis C virus carriers presenting cryoglobulinaemia and non-organ-specific autoantibodies |
Other Titles: | Microbial Pathogenesis |
Authors: | Atta, Ajax Mercês Oliveira, Isabela S. Sousa, Gabriel Menezes de Paraná, Raymundo Atta, Maria Luiza Brito de Sousa |
metadata.dc.creator: | Atta, Ajax Mercês Oliveira, Isabela S. Sousa, Gabriel Menezes de Paraná, Raymundo Atta, Maria Luiza Brito de Sousa |
Abstract: | This work investigated the serum cytokine profile (IL-2, IL-4, IL-5, IL-10, IFN-γ and BAFF) of hepatitis C virus (HCV) carriers with autoimmunity. Forty-seven HCV carriers and 28 healthy controls were evaluated. Cytokine levels were measured by ELISA. Patients and controls presented similar levels of IL-2, IL-4, IL-5, IL-10, IFN-γ and BAFF (p > 0.05). Cryoglobulinaemic HCV carriers had increased IL-2 (p = 0.013), IL-5 (p = 0.018) and BAFF (p = 0.050). IFN-γ level was decreased in HCV carriers with rheumatoid factor in comparison with those that were RF-seronegative (p = 0.035). Patients with β2GPI IgA antibodies when were compared with those without this autoantibody, had more serum IL-2 (p = 0.009), IL-5 (p = 0.018) and BAFF (p = 0.039). Interleukin-2 was increased in HCV carriers with positive ANA when they were compared with ANA-seronegative carriers (p = 0.044). Interleukins IL-4 and IL-10 were not associated with autoimmunity (P > 0.05). In HCV carriers, IL-2 was correlated with IL-5 (p < 0.0001) and IFN-γ (p = 0.015), and IL-5 with IFN-γ (p = 0.015). We concluded that the serum profile of cytokines in HCV carriers presenting autoimmune markers may be mainly represented by increased IL-2, IL-5 and BAFF. |
Keywords: | Hepatitis C Autoimmunity Cryoglobulinaemia Autoantibody Cytokine |
Publisher: | Elsevier |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/6048 |
Issue Date: | Feb-2010 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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(46)1-s2.0-S0882401009002022-main.pdf Restricted Access | 214,55 kB | Adobe PDF | View/Open Request a copy |
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