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https://repositorio.ufba.br/handle/ri/5924
metadata.dc.type: | Artigo de Periódico |
Title: | Exploiting iminoquinone free radical production for thiol based drugs determination in pharmaceutical formulations |
Other Titles: | Journal of the brazilian chemical society |
Authors: | Chagas, Manoel Pinheiro Santos, Josué Carinhanha Caldas Santos, Eduardo B. G. N. Oliveira, Tiago D. Korn, Mauro |
metadata.dc.creator: | Chagas, Manoel Pinheiro Santos, Josué Carinhanha Caldas Santos, Eduardo B. G. N. Oliveira, Tiago D. Korn, Mauro |
Abstract: | A spectrophotometric flow analysis procedure to determine Captopril (CPT) and N-acetyl-L-cysteine (NAC) in pharmaceutical formulations was developed based on the reaction with iminoquinone radical produced from the N,N-dimethyl-p-phenilenediamene (DMPD) oxidation in acid medium. The reagents addition order was evaluated and analytical parameters were optimized. The linear concentrations ranges were 2.5-90 and 5.0-50 mg L-1 for CPT and NAC, respectively. Limits of detection (3σ) were calculated at 0.22 and 1.8 mg L-1 and the relative standard deviation (N = 10) were lower than 1.0 and 2.1% for CPT and NAC, respectively. The procedure was employed for CPT and NAC determination in diverse pharmaceutical formulations and by applying paired t-test the results were in agreement with those obtained by reference methods for 95% confidence level. |
Keywords: | Iminoquinone radical reaction Flow injection analysis Determination of thiol drugs Captopril |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/5924 |
Issue Date: | 2009 |
Appears in Collections: | Artigo Publicado em Periódico (Química) |
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__www.scielo.br_pdf_jbchs_v20n9_12.pdf | 206,9 kB | Adobe PDF | View/Open |
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