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metadata.dc.type: | Artigo de Periódico |
Title: | Hippocampal volume in borderline personality disorder with and without comorbid posttraumatic stress disorder: A meta-analysis |
Other Titles: | European Psychiatry |
Authors: | Sena, Eduardo Pondé de Quarantini, Lucas de Castro Oliveira, Irismar Reis de Scippa, Ângela Marisa de Aquino Miranda Rodrigues, E. Wenzel, A. Ribeiro, M. P. |
metadata.dc.creator: | Sena, Eduardo Pondé de Quarantini, Lucas de Castro Oliveira, Irismar Reis de Scippa, Ângela Marisa de Aquino Miranda Rodrigues, E. Wenzel, A. Ribeiro, M. P. |
Abstract: | Background: Several studies have found a reduction in hippocampal volume in borderline personality disorder (BPD) patients. Methods: In order to investigate the degree to which comorbid posttraumatic stress disorder (PTSD) could account for reduction in hippocampal volume in these patients, we conducted a systematic review and meta-analysis of studies that compared hippocampal volume in BPD patients with and without PTSD relative to healthy controls. Results: Seven articles, involving 124 patients and 147 controls, were included. We found a statistically significant reduction for the left and right hippocampus. Data from the four studies that discriminated BPD patients with and without PTSD indicate that hippocampal volumes were reduced bilaterally in BPD patients with PTSD, relative to healthy controls, but that results were mixed for BPD patients without PTSD, relative to healthy controls. Conclusions: Results from this meta-analysis suggest that hippocampal volumes are reduced in patients with BPD, relative to healthy controls, but particularly in cases in which patients are diagnosed with comorbid PTSD. |
Keywords: | Meta-analysis Hippocampus Borderline personality disorder Magnetic resonance imaging Posttraumatic stress disorder |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/5400 |
Issue Date: | 2011 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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__pdn.sciencedirect.com_....0-S0924933810001495-main.pdf Restricted Access | 314,85 kB | Adobe PDF | View/Open Request a copy |
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