Por favor, use este identificador para citar o enlazar este ítem:
https://repositorio.ufba.br/handle/ri/4816
metadata.dc.type: | Artigo de Periódico |
Título : | Schistosoma mansoni Infection Modulates the Immune Response against Allergic and Auto-immune Diseases |
Otros títulos : | Memórias do Instituto Oswaldo Cruz |
Autor : | Araujo, Maria Ilma Andrade Santos Hoppe, Bradford S. Medeiros Junior, Manoel Carvalho Filho, Edgar Marcelino de |
metadata.dc.creator: | Araujo, Maria Ilma Andrade Santos Hoppe, Bradford S. Medeiros Junior, Manoel Carvalho Filho, Edgar Marcelino de |
Resumen : | Chronic Schistosoma mansoni infection leads to a type 2-immune response with increased production of interleukin (IL-10). Evidence indicates chronic exposure to S. mansoni down regulates the type 1 immune response and prevents the onset of Th1-mediated diseases such as multiple sclerosis, diabetes mellitus and Cronh’s disease. Furthermore, our own studies have revealed that chronic exposure to S. mansoni also down regulates atopic disease, Th2-mediated diseases. Our studies show an inverse association between the skin prick test reactivity and infection with S. mansoni and show the severity of asthma is reduced in subjects living in an endemic area of S. mansoni. Moreover, we hypothesize the mechanisms involved in the modulation of inflammatory response in atopic individuals, is likely dependent on IL-10 production, an anti-inflammatory cytokine elevated during helminth infections. Patients with asthma and helminth infections produced less IL-5 than patients with asthma without helminth infections, and this down regulation could, in part, be mediated by IL-10. In conclusion, helminthic infections, through induction of regulatory mechanisms, such as IL-10 production, are able to modulate the inflammatory immune response involved in the pathology of auto-immune and allergic disease. |
Palabras clave : | Schistosoma mansoni alergic disease asthma auto-immune diseases |
URI : | http://www.repositorio.ufba.br/ri/handle/ri/4816 |
Fecha de publicación : | 2004 |
Aparece en las colecciones: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
v99s1a05.pdf | 46,56 kB | Adobe PDF | Visualizar/Abrir |
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.