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https://repositorio.ufba.br/handle/ri/5317
metadata.dc.type: | Artigo de Periódico |
Title: | Increased concentrations of IL-18 and uric acid in sickle cell anemia: Contribution of hemolysis, endothelial activation and the inflammasome |
Other Titles: | Cytokine |
Authors: | Cerqueira, Bruno A. V. Gonçalves, Marilda Souza Vilas Boas, Wendell Zanette, Angela Maria Dias Reis, Mitermayer Galvão dos |
metadata.dc.creator: | Cerqueira, Bruno A. V. Gonçalves, Marilda Souza Vilas Boas, Wendell Zanette, Angela Maria Dias Reis, Mitermayer Galvão dos |
Abstract: | Sickle cell anemia (SCA) is a common, severe monogenetic disorder characterized by chronic hemolysis, frequent infections, a chronic inflammatory state and recurrent occlusions of the microcirculation, result- ing in painful crises, organ damage and premature death. This study evaluated associations between serum levels of IL-18, uric acid, hemolytic markers, and inflammatory molecules in SCA patients. A cross-sectional study was performed including 45 SCA patients (median age of 20.5 years) without gen- eral symptoms and who had not undergone blood transfusions. Inclusion criteria for the steady-state SCA patients were the absence of hospitalization and the absence of infections. Interleukin-18 and uric acid levels were correlated closely with markers of hemolysis, endothelial dysfunction and others cytokines levels. These findings suggest probable influences of IL-18 and uric acid in the pathophysiology of vascu- lar occlusion in SCA. Additional studies should be performed to characterize similar prognosis markers and possible therapeutic targets. |
Keywords: | Sickle cell anemia Cytokine Inflammation |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/5317 |
Issue Date: | 2011 |
Appears in Collections: | Artigo Publicado em Periódico (FAR) |
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__pdn.sciencedirect.com_....0-S1043466611006764-main.pdf Restricted Access | 263,86 kB | Adobe PDF | View/Open Request a copy |
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