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metadata.dc.type: | Artigo de Periódico |
Title: | American Cutaneous Leishmaniasis unresponsive to antimonial drugs: successful treatment using combination of N-Methilglucamine Antimoniate plus Pentoxifylline |
Other Titles: | International Journal of Dermatology |
Authors: | Báfica, Andre Luiz Barbosa Oliveira, Luiz Fabiano Borges Freitas, Luiz Antonio Rodrigues de Nascimento, Eliane G. Barral, Aldina Maria Prado |
metadata.dc.creator: | Báfica, Andre Luiz Barbosa Oliveira, Luiz Fabiano Borges Freitas, Luiz Antonio Rodrigues de Nascimento, Eliane G. Barral, Aldina Maria Prado |
Abstract: | Background American cutaneous leishmaniasis is characterized by single or multiple ulcerations. Cytokines, among other factors, have been shown to influence lesion development and tumoral necrosis factor-alpha is a major cytokine implicated in pathogenesis of ulcers. Observations We tested oral pentoxifylline, a known tumoral necrosis factor-alpha inhibitor, at doses of 400 mg (2–3x/day), associated to N-methylglucamine antimoniate (15 mg/kg/day) in two patients with American cutaneous leishmaniasis unresponsive to antimonial drugs. We observed a satisfactory response with quick cure of skin lesions of these patients. Conclusions Our results suggest that oral pentoxifylline in association to N-methylglucamine antimoniate should be consider in refractory cutaneous leishmaniasis patients. |
Keywords: | Leishmaniasis, Cutaneous Ulcer Pentoxifylline |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/16672 |
Issue Date: | 2003 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Files in This Item:
File | Description | Size | Format | |
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André Báfica.pdf | 236,56 kB | Adobe PDF | View/Open |
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