Please use this identifier to cite or link to this item:
https://repositorio.ufba.br/handle/ri/16556
metadata.dc.type: | Artigo de Periódico |
Title: | The fragility of protein-protein interaction networks |
Other Titles: | EPL |
Authors: | Andrade, Roberto Fernandes Silva Schneider, C. M. Shinbrot, T. Herrmann, H. J. |
metadata.dc.creator: | Andrade, Roberto Fernandes Silva Schneider, C. M. Shinbrot, T. Herrmann, H. J. |
Abstract: | The capacity to resist perturbations from the environment is crucial to the survival of all organisms. We quantitatively analyze the susceptibility of protein interaction networks of numerous organisms to random and targeted failures. We find for all organisms studied that random rewiring improves protein network robustness, so that actual networks are more fragile than rewired surrogates. This unexpected fragility contrasts with the behavior of networks such as the Internet, whose robustness decreases with random rewiring. We trace this surprising effect to the modular structure of protein networks. |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/16556 |
Issue Date: | 2011 |
Appears in Collections: | Artigo Publicado em Periódico (FIS) |
Files in This Item:
File | Description | Size | Format | |
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R. F. S. Andrade.pdf | 1,54 MB | Adobe PDF | View/Open |
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