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https://repositorio.ufba.br/handle/ri/14902
metadata.dc.type: | Artigo de Periódico |
Title: | Porphyromonas gingivalis HmuY stimulates expression of Bcl-2 and Fas by human CD3+ T cells |
Other Titles: | BMC Microbiology |
Authors: | Carvalho Filho, Paulo Cirino de Trindade, Soraya Castro Olczak, Teresa Sampaio, Geraldo P. Oliveira Neto, Milton G. Santos, Heidiane Alves dos Pereira, Bianca F. P. Costa, Lilia Moura Xavier, Márcia Tosta Nascimento, Roberto José Meyer |
metadata.dc.creator: | Carvalho Filho, Paulo Cirino de Trindade, Soraya Castro Olczak, Teresa Sampaio, Geraldo P. Oliveira Neto, Milton G. Santos, Heidiane Alves dos Pereira, Bianca F. P. Costa, Lilia Moura Xavier, Márcia Tosta Nascimento, Roberto José Meyer |
Abstract: | Background: Apoptosis is a highly controlled process of cell death that can be induced by periodontopathogens. The present study aimed to investigate the expression of Fas and Bcl-2 proteins by CD3+ T cells in vitro under stimulation by total Porphyromonas gingivalis antigens and purified recombinant P. gingivalis HmuY protein. Results: CD3+ T cells derived from CP patients and stimulated with HmuY expressed higher levels of Bcl-2 compared to identical cells stimulated with P. gingivalis crude extract or cells derived from NP control subjects (p = 0.043). Conclusion: The authors hypothesize that P. gingivalis HmuY plays a role in the pathogenesis of chronic periodontitis, possibly by reducing or delaying apoptosis in T cells through a pathway involving the Bcl-2 protein. |
Keywords: | Porphyromonas gingivalis HmuY Bcl-2 Fas Apoptosis |
metadata.dc.publisher.country: | Brasil |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/14902 |
Issue Date: | 2013 |
Appears in Collections: | Artigo Publicado em Periódico Estrangeiro (ISC) |
Files in This Item:
File | Description | Size | Format | |
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1471-2180-13-206.pdf | 344,36 kB | Adobe PDF | View/Open |
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