Marcadores histológicos de cronicidade e progressão na glomeruloesclerose segmentar e focal

Abstract

Segmental and focal glomerulosclerosis not otherwise specified (FSGS NOS) is a glomerulopathy with undefined outcome. We reviewed possible histopathological markers of chronicity from the literature and identified 33 cases of FSGS NOS for our sample. Based on the frequency of certain markers, we developed an experimental scoring system that uses tubular atrophy, interstitial fibrosis, glomerular hyalinosis, arteriolosclerosis, and glomerular sclerosis. We applied an experimental scoring system to predict chronicity. Our analysis revealed a sensitivity of 0.66 and a specificity of 0.80. Glomerular hyalinosis emerged as the most reliable isolated parameter, with a sensitivity of 0.83 and a specificity of 0.70. We obtained a survey of risk mutation of APOL1 genes from 25 of 33 patients. Additionally, we conducted our specimen in scanning for future endeavors in digital pathology for AI training.