Estudo da reatividade do timol e carvacrol em reações de substituição eletrofílica aromática e aplicações sintéticas.

Abstract

Thymol and carvacrol are phenolic monoterpenes consisting of a six-membered aromatic ring substituted by a hydroxyl group, an isopropyl group, and a methyl group. Besides their low cost and wide availability, both stand out for the significant diversity of biological activities observed in their derivatives, reinforcing the interest in exploring their synthetic potential. In this context, this work investigated thereactivity of thymol and carvacrol under sustainable conditions, focusing on electrophilic aromatic substitution reactions. Among the transformations studied, nitration presented the most promising results with yields between 30 and 55%, allowing the determination of alternative routes for the synthesis of mononitrated and dinitrated products.