Eficácia e segurança do dimesilato de lisdexanfetamina no tratamento do TDAH em adultos: revisão sistemática

Abstract

Introduction: In childhood, Attention Deficit Hyperactivity Disorder (ADHD) is characterized by inattention, hyperactivity and impulsivity. In adulthood, the demands of life ask for more frequent and complex requirements, and show problems due to inattention, while decreasing hyperactivity and / or impulsivity. ADHD in adults, although already with scientific support, is still a reason for controversy among specialists. Most of the existing knowledge is still due to the extrapolation of the findings of studies with populations of children or adolescents and that is why we need new studies in the adult population. Psychostimulant therapies are considered as reference in the treatment of the disorder in adults. The pro-drug lisdexamphetamine dimesylate is one of the drugs used for the treatment of ADHD. Objectives: To analyze the efficacy and safety of lisdexamphetamine in the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in adults. Methodology: In this systematic literature review, clinical trials, observational (cohort or case-control) studies with adult ADHD subjects using lisdexamphetamine dimesylate were considered. English and Portuguese texts were considered in our search. Results: Of the 32 articles identified, 4 articles were included in the systematic literature review. All studies have demonstrated similar results regarding the efficacy and safety of lisdexamphetamine dimesylate in the treatment of ADHD in adults. For this, different scales of evaluation and frequency of adverse effects were used. Conclusion: Lisdexamphetamine dimesylate was shown to be effective and safe in the treatment of ADHD in adults. All studies converged on their results. There is still little availability of studies related to the topic.