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Campo DC | Valor | Idioma |
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dc.contributor.author | Reed, Steven G. | - |
dc.contributor.author | Roters, Silene B. | - |
dc.contributor.author | Inverso, Jill A. | - |
dc.contributor.author | Jones, Thomas C. | - |
dc.contributor.author | Goidl, Edmond A. | - |
dc.creator | Reed, Steven G. | - |
dc.creator | Roters, Silene B. | - |
dc.creator | Inverso, Jill A. | - |
dc.creator | Jones, Thomas C. | - |
dc.creator | Goidl, Edmond A. | - |
dc.date.accessioned | 2013-02-21T13:02:52Z | - |
dc.date.available | 2013-02-21T13:02:52Z | - |
dc.date.issued | 1985 | - |
dc.identifier.issn | 0008-8749 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/8590 | - |
dc.description | Texto completo. Acesso restrito. p. 12–25 | pt_BR |
dc.description.abstract | Antibody responses to T-dependent and T-“independent” antigens were studied in diseasesusceptible (BALB/c and C57BL/lO) and disease-resistant (A/J) mice infected with Leishmania donovani chagasi. Disease-susceptible mice but not disease-resistant mice showed a transient decrease in PFC responses to TNP on a T-dependent carrier (BGG) during the period of 4-8 weeks after infection. Infected disease-susceptible animals also showed increased responses to TNP on a type II T-independent carrier (Ficoll), which persisted until at least 14 weeks after infection. The increased responses were associated with a significant increase in anti-TNP antibody of the lgG2b subclass. When T-enriched spleen cells from infected mice and B-enriched spleen cells from uninfected mice were transferred to irradiated recipients immunized with TNP-Ficoll, increased anti-TNP PFC were observed over numbers seen in irradiated recipients which received both B and T cells from uninfected mice. Increased responses to TNP-Ficoll were also induced by prior administration of soluble leishmania extract in CFA. Infected mice immunized with TNP-LPS, a T-independent type I antigen, also had increased anti-TNP antibody responses, but had normal anti-LPS antibody responses. The elevated antibody production which occurred in response to the T-“independent” antigens could not be attributed to the relatively low polyclonal response which occurred in both disease-resistant and disease-susceptible mice infected with L. donovani chagasi. The observations are consistent with leishmania induced, transient alterations in some T-cell functions including response to haptens on T-dependent carriers, and a lack of down regulation of T-“independent” responses. Subtle lesions in immunoregulation may be important correlates of successful protozoa1 infection and may be responsible for some of the immunologic manifestations of the disease | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | Cellular Immunology | pt_BR |
dc.source | http://dx.doi.org/10.1016/0008-8749(85)90336-3 | pt_BR |
dc.title | Immune responses to T-dependent and T-independent antigens during visceral leishmaniasis in mice: Evidence for altered T-cell regulation of immune responses to non-parasite antigens | pt_BR |
dc.title.alternative | Cellular Immunology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.description.localpub | Salvador | pt_BR |
dc.identifier.number | v. 96, n. 1 | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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Arquivo | Descrição | Tamanho | Formato | |
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7777777.pdf | 1,83 MB | Adobe PDF | Visualizar/Abrir |
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