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Campo DC | Valor | Idioma |
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dc.contributor.author | Lima, Flávia Oliveira de | - |
dc.contributor.author | Nonato, Fabiana Regina | - |
dc.contributor.author | Couto, Ricardo David | - |
dc.contributor.author | Barbosa Filho, José Maria | - |
dc.contributor.author | Nunes, Xirley Pereira | - |
dc.contributor.author | Santos, Ricardo Ribeiro dos | - |
dc.contributor.author | Soares, Milena Botelho Pereira | - |
dc.contributor.author | Villarreal, Cristiane Flora | - |
dc.creator | Lima, Flávia Oliveira de | - |
dc.creator | Nonato, Fabiana Regina | - |
dc.creator | Couto, Ricardo David | - |
dc.creator | Barbosa Filho, José Maria | - |
dc.creator | Nunes, Xirley Pereira | - |
dc.creator | Santos, Ricardo Ribeiro dos | - |
dc.creator | Soares, Milena Botelho Pereira | - |
dc.creator | Villarreal, Cristiane Flora | - |
dc.date.accessioned | 2012-03-02T12:23:00Z | - |
dc.date.available | 2012-03-02T12:23:00Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0974-5211 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/5487 | - |
dc.description | p. 596-602 | pt_BR |
dc.description.abstract | 7-Hydroxycoumarin (umbelliferone, 1), the main metabolite of coumarin, has been reported to produce potent antinociceptive effects in animal models of pain. However, the biochemical events involved in antinociception mediated by 1 are currently not well understood. In the present study, the mechanisms by which 1 exerts its pharmacological actions were investigated. Acute pretreatment of mice with 1 produced a long-lasting antinociceptive effect against complete Freund’s adjuvant (CFA)-induced hyperalgesia. The subchronic administration of 1 inhibited CFA-induced hyperalgesia and paw edema, while it did not cause any apparent toxicity. Another set of experiments showed that 1 inhibited carrageenan-induced mechanical hyperalgesia, but not mechanical hyperalgesia induced by prostaglandin E2 (PGE2), suggesting that it acts upstream of PGE2. Treatment with 1 was able to prevent the plantar tissue neutrophil influx induced by local inflammatory stimuli. In addition, 1 exhibited inhibitory effects on the release of hyperalgesic cytokines (TNF-R and IL-1β) and the production of PGE2, a directly acting hyperalgesic mediator. The present results suggest that the antinociceptive effect of 1 is correlated with the inhibition of neutrophil migration, cytokine release, and PGE2 production and are supportive of the further investigation of the therapeutic potential of 1 to control inflammatory pain. | pt_BR |
dc.language.iso | en | pt_BR |
dc.source | DOI: 10.1021/np100621c | pt_BR |
dc.title | Mechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin | pt_BR |
dc.title.alternative | JOURNAL OF NATURAL PRODUCTS | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 74, n. 4. | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Química) |
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