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Campo DC | Valor | Idioma |
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dc.contributor.author | Cruz, Ebenézer de Mello | - |
dc.contributor.author | Silva, Edson Roberto da | - |
dc.contributor.author | Maquiaveli, Claudia do Carmo | - |
dc.contributor.author | Alves, Eliomara Sousa Sobral | - |
dc.contributor.author | Lucon Junior, João Francisco | - |
dc.contributor.author | Reis, Matheus Balduino Gonçalves dos | - |
dc.contributor.author | Toledo, Cleyton Eduardo Mendes de | - |
dc.contributor.author | Cruz, Frederico Guare | - |
dc.contributor.author | Santos, Marcos André Vannier dos | - |
dc.creator | Cruz, Ebenézer de Mello | - |
dc.creator | Silva, Edson Roberto da | - |
dc.creator | Maquiaveli, Claudia do Carmo | - |
dc.creator | Alves, Eliomara Sousa Sobral | - |
dc.creator | Lucon Junior, João Francisco | - |
dc.creator | Reis, Matheus Balduino Gonçalves dos | - |
dc.creator | Toledo, Cleyton Eduardo Mendes de | - |
dc.creator | Cruz, Frederico Guare | - |
dc.creator | Santos, Marcos André Vannier dos | - |
dc.date.accessioned | 2013-06-13T19:33:48Z | - |
dc.date.available | 2013-06-13T19:33:48Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0031-9422 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/11923 | - |
dc.description | Texto completo. Acesso restrito. p. 71–77 | pt_BR |
dc.description.abstract | The plant Cecropia pachystachya Trécul is widely used in Brazilian ethnomedicine to treat hypertension, asthma, and diabetes. Arginase is an enzyme with levels that are elevated in these disorders, and it is central to Leishmania polyamine biosynthesis. The aims of this study were to evaluate antileishmanial activity and inhibition of the arginase enzyme by C. pachystachya extracts, and to study changes in cellular organization using electron microscopy. The ethanol extract of C. pachystachya was tested on Leishmania (Leishmania) amazonensis promastigote survival/proliferation and arginase activity in vitro. Qualitative ultrastructural analysis was also used to observe changes in cell organization. The major bioactive molecules of the ethanol extract were characterized using liquid chromatography–electrospray ionizationmass spectrometry (LC–ESI-MS). The ethyl acetate fraction of the ethanol extract diminished promastigote axenic growth/survival, inhibited arginase activity, and altered a mitochondrial kinetoplast DNA (K-DNA) array. The bioactive compounds of C. pachystachya were characterized as glucoside flavonoids. Orientin (9) (luteolin-8-C-glucoside) was the main component of the methanol-soluble ethyl acetate fraction obtained from the ethanol extract and is an arginase inhibitor (IC50 15.9 lM). The ethyl acetate fraction was not cytotoxic to splenocytes at a concentration of 200 lg/mL. In conclusion, C. pachystachya contains bioactive compounds that reduce the growth of L. (L.) amazonensis promastigotes, altering mitochondrial K-DNA arrangement and inhibiting arginase. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | Phytochemistry | pt_BR |
dc.source | http://dx.doi.org/10.1016/j.phytochem.2013.01.014 | pt_BR |
dc.subject | Cecropia pachystachya | pt_BR |
dc.subject | Cecropiaceae | pt_BR |
dc.subject | Arginase | pt_BR |
dc.subject | Polyamines | pt_BR |
dc.subject | Oxidative stress | pt_BR |
dc.subject | Kinetoplast | pt_BR |
dc.subject | Ultrastructure | pt_BR |
dc.subject | Leishmania | pt_BR |
dc.title | Leishmanicidal activity of Cecropia pachystachya flavonoids: Arginase inhibition and altered mitochondrial DNA arrangement | pt_BR |
dc.title.alternative | Phytochemistry | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.description.localpub | Salvador | pt_BR |
dc.identifier.number | v. 89 | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Química) |
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